Tight Muscles, Night Leg Cramps, Restless Body? Start Here.

If you’re tired of waking up exhausted after another night of tossing and turning, GloSerene’s Magnesium Glycinate delivers ~275mg of elemental magnesium to relax tight muscles, calm your wired nervous system, and support deeper sleep—without upsetting your stomach.*

GloSerene, Masnesium Glycinate, 90 capsules
  • Fewer night leg cramps and less tension — your body stops fighting you when you lie down, so you can actually get comfortable.*
  • Soothe your anxious, racing mind — magnesium + glycine supports calming neurotransmitters, helping you shift out of “on edge” mode so sleep feels easier.*
  • Gentle on your stomach, easy to stick with — highly absorbable, easier on digestion than oxide or citrate. Take it daily for best results, or just on nights you need extra muscle support.*
Calm My Muscles, Calm My Night

They Were Ready to Give Up. Then They Tried One More Thing.

Tight muscles. Restless legs. Hips that won’t relax. Every night feels like a battle you’re losing.

These women were losing too—until they gave their bodies what they actually needed to calm down.

“Honestly scared to try—I’m sensitive. But anxiety + restless legs were killing me. Friend (naturopath) said ‘glycinate is gentle, start with 1 cap.’ Did that for a week, then 2. Took 3 weeks but huge improvement: anxiety down, legs calm, sleeping 6+ hours. Worth it.”

Amara N., 48

Verified Buyer

“I don’t usually leave reviews, but I have to. After 3 years of bad sleep and tight muscles, I thought ‘this is just my life now.’ My acupuncturist suggested GloSerene. I was skeptical—nothing ever worked. But this did. My body is calm now. I didn’t know calm was still possible for me.”

Lin H., 50

Verified Buyer

“Couldn’t get comfortable—toss, turn, legs cramping, repeat. My prayer group said ‘keep faith.’ One sister gave me GloSerene. Week 2: tossing stopped. Week 4: cramps gone. Week 6: leading Bible study without exhaustion fog. That sister didn’t just give me magnesium—she gave me my nights back.”

Tiffany M., 47

Verified Buyer

“I’m a physician—I know magnesium oxide is poorly absorbed. Recommended glycinate to patients for years. Finally took my own advice at 53. Week 3: muscle tension down, sleeping better. My RN colleague asked ‘what changed?’ I said ‘practicing what I preach!’ Evidence works.”

Dr. Janice L., 53

Verified Buyer

“I’m Latina, always tense in my shoulders and calves. Nights were just toss-and-turn marathons. With GloSerene my body actually lets go. I still wake up sometimes, but I fall back asleep instead of scrolling TikTok at 3AM. I’m less grumpy with my kids in the mornings too.”

Mariela G., 46

Verified Buyer
Help Your Body Finally Relax

🌾 Gluten Free

🌱 Non GMO

💸 90-Day Money-Back Guarantee

🇺🇸 Manufactured in USA

💜 Customer Favorite

⭐ 5-Star Reviews

🚚 Free shipping $50+

🦠 Antibiotic Free

🚫 No Artificial Colors

⏱️ Fast-acting formula

🌙 Better Sleep*

💪 Muscle Relaxation*

🦵 Helps Night Leg Cramps*

🌊 Eases Racing Thoughts*

🌿 Nervous System Support*

😌 Promotes Relaxation*

💭 Quiet Mind Support*

⏱️ Fall Asleep Faster

🚫 No Laxative Effect

✨ Easily Absorbed

🫧 Gentle on Most Stomachs

★ ★ ★ ★ ★
4.8 from 500+ verified reviews

GloSerene™ Muscle Calm & Body Ease

GloSerene™ Muscle Calm & Body Ease

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check_circle Deeper, more restorative sleep*

check_circle Less tossing, fewer cramps*

check_circle Helps relax tight muscles*

check_circle Helps quiet a busy mind*

check_circle Gentle on stomach - No laxative effect

check_circle 80% better absorbed than magnesium oxide

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Payment logos: Amex, Mastercard, PayPal, OPay, Google Pay, Apple Pay, Discover, Visa.
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What you get

💊 90 Capsules Per Bottle

30-day supply when taken as directed (3 capsules daily)

🔬 275mg Elemental Magnesium Per Serving

The clinically-studied dose proven to help you fall asleep faster, sleep longer, and wake up refreshed.*

✨ 20x More Absorbable

Chelated glycinate—absorbs better, works where needed*

🌱 Gentle on Your Stomach

No upset stomach. No laxative effect. Just restful sleep.

🇺🇸 Made in USA

GMP-certified, FDA-registered facility.

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How to take GloSerene

For Best Results:

⏰ When: Take 3 capsules once daily, 1-2 hours before bedtime

🍽️ With or Without Food: Take with dinner or a light snack to maximize absorption and minimize any stomach sensitivity

💧 With Water: Take with 8oz of water for optimal absorption

📅 Consistency is Key: Take daily for at least 2-4 weeks to experience full benefits

💡 Pro Tip: If 3 capsules at once feels like too many, you can split the dose (1-2 earlier in the day + 1-2 at night)

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What to Expect

🦵 Muscle Cramps & Restless Legs

• 24-48 hours: Many women notice initial relief

• 1 week: Significant reduction in frequency and intensity

😴 Sleep Quality

• Few hours: Some feel a calming effect the first night

• 1-2 weeks: Noticeable improvements in falling asleep and sleep duration

• 4-8 weeks: Consistent, sustained improvements—this is your new normal

🧘 Calm & Stress Relief

• 1-7 days: Subtle sense of calm begins

• 2-4 weeks: Anxiety and racing thoughts significantly reduced

• 4-8 weeks: Mood stabilizes, stress feels more manageable

💪 Overall Wellbeing

• 4-8 weeks: Energy, mood, focus all improve as magnesium stores rebuild

• 8+ weeks: Long-term benefits for bone health, blood pressure, heart health

💡 Why the Wait?

You’re not just masking symptoms—you’re rebuilding your body’s magnesium stores. That takes time, but the results last as long as you supplement consistently.

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Shipping & Delivery

Ships in 24–48 hours. U.S. delivery in 5–7 business days.

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90-Day Money-Back Guarantee

Try it risk-free for 3 full months—if you don't sleep better, we refund every penny.

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Most Midlife Women Feel This. Here’s the Missing Piece.

If you’re dealing with even a few of these—extreme fatigue, muscle pain, night cramps, poor sleep—you’re not alone. You’re in the majority.

People blame age, hormones, or “just stress.” But here’s what no one tells you: when magnesium runs low (from stress, caffeine, and hormonal shifts), your muscles, nerves—even sleep—struggle to reset at night.

Do any of these sound too familiar?

  • 🔥 Legs that cramp or “lock up” the minute you lie down
  • 💥 Restless, buzzing legs that won’t stay still
  • 😴 Tossing and turning, can’t shut your body down
  • 🧱 Waking up sore, stiff, and still tired
  • ⚡ Energy crashing by mid-afternoon
  • 💔 Feeling like your body is fighting against you every night

Painkillers just cover it up. Sleeping pills “knock you out.” But if your body’s out of magnesium, the same issues return again and again.

GloSerene is designed to help fill that magnesium gap—so your body finally has what it needs to relax at night, not just endure another battle with your bed.*

From Dragging… to Rested


Before After
Leg cramps jolt you awake most nights Legs feel calmer; nights are less interrupted
Body can’t get comfortable in bed Muscles loosen so you can actually settle in
Tossing and turning for hours Falling asleep feels easier and sleep feels deeper*
Wake up stiff, sore, and exhausted Wake up less tight and more refreshed*
Crashing by 2 p.m. Energy holds into the evening*
Dread going to bed Bedtime feels like relief again, not another fight

Most women start noticing calmer legs and deeper sleep within 2–4 weeks of nightly use.*

What makes GloSerene different?

Instead of just masking symptoms, GloSerene gives your body:

  • Deeper sleep improvement: Fall asleep easier, wake up restored.
  • Muscle + nerve comfort: Less cramping and tension, both day and night.
  • Daily energy & mood: Support physical and mental energy so you can feel present—not just push through.
  • Long-term wellness: Gentle support for bones, heart, and your body’s stress response.

No grogginess, no habit-forming drugs, and stomach-friendly—just the magnesium support your midlife body craves.

Ready to finally relax at night—and wake up feeling good again?

Let My Body Finally Relax

How GloSerene Works in Real Life

78%

Felt calmer and more relaxed in the evenings

“I’m not so wound up by bedtime.”
80%

Had fewer night-time leg cramps and restless legs

“Legs finally calm down when I lie down.”
82%

Slept faster and deeper

“Not fighting my bed for hours anymore.”
87%

Woke up with less muscle tension and stiffness

“Morning aches aren’t running my day.”
91%

Experienced no stomach discomfort or laxative effects

“Gentle enough for my sensitive stomach.”
Calm My Legs, Calm My Night

*Based on a customer survey of women ages 45-60 who used GloSerene consistently for 21-90 days. Individual results may vary. These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.

“My Legs Finally Calm Down”

Claire M., 45
“At first, I just wanted relief from leg cramps. After a month, I noticed my mood steadied and my anxiety eased. This isn’t just a supplement—it’s become my nightly self-care ritual.”
Claire M., 45

Verified Buyer

Shaniqua M., 48
“Girl, I was skeptical but this stuff took those night cramps away fast! No more leg jerks waking me up. Plus, I’m way less stressed at night. Feels like my mind is finally chillin’—mad grateful.”
Shaniqua M., 48

Verified Buyer

Sophia R., 52
“Immediate difference in sleep quality and no more morning stiffness. Even my headaches have reduced. The best part? No tummy troubles like with other mag supplements.”
Sophia R., 52

Verified Buyer

Maria V., 50
“I didn’t realize how much my leg cramps were affecting my mood until after a few weeks using GloSerene. Now, I’m calmer and more patient with my kids. Sleeping better truly gave me back my joy.”
Maria V., 50

Verified Buyer

Kelly R., 52
“I’m a nurse on my feet all day, and my legs would seize up the second I lay down. After the first week on GloSerene, the cramps backed off; by week 3 I was sleeping straight through most nights. The ... “I’m a nurse on my feet all day, and my legs would seize up the second I lay down. After the first week on GloSerene, the cramps backed off; by week 3 I was sleeping straight through most nights. The surprise bonus? I’m not snapping at my patients from sheer exhaustion anymore.”
Kelly R., 52

Verified Buyer

Ana María V., 47
“I was scared to try magnesium because of my super-sensitive stomach. GloSerene has been gentle for me. First, my shoulders and jaw weren’t so tight at night. Then I realized I was waking up with ener... “I was scared to try magnesium because of my super-sensitive stomach. GloSerene has been gentle for me. First, my shoulders and jaw weren’t so tight at night. Then I realized I was waking up with energy to walk the dog and do yoga again. I feel more like myself, not just a tired mom.”
Ana María V., 47

Verified Buyer

Mei L., 46 
“I sit at a desk all day; by bedtime, my neck and shoulders felt like concrete. GloSerene didn’t knock me out—it just made my body feel… quieter. Less twitching, less tension. I’m getting 6–7 solid ho... “I sit at a desk all day; by bedtime, my neck and shoulders felt like concrete. GloSerene didn’t knock me out—it just made my body feel… quieter. Less twitching, less tension. I’m getting 6–7 solid hours instead of broken 4s, and I’m not living on coffee refills anymore.”
Mei L., 46 

Verified Buyer

Ananya S., 51
“The muscle cramps were brutal. After months on GloSerene, I feel less tense both physically and mentally. Not just my sleep, but my concentration and mood swings have improved. Subtle but life-changi... “The muscle cramps were brutal. After months on GloSerene, I feel less tense both physically and mentally. Not just my sleep, but my concentration and mood swings have improved. Subtle but life-changing.”
Ananya S., 51

Verified Buyer

Sofia R., 44
“Midlife hit and my sleep went to trash—tossing, turning, leg cramps, bathroom trips. This didn’t fix everything but took a big layer off. My body feels heavy-relaxed instead of jerky, so whatever hou... “Midlife hit and my sleep went to trash—tossing, turning, leg cramps, bathroom trips. This didn’t fix everything but took a big layer off. My body feels heavy-relaxed instead of jerky, so whatever hours I get feel deeper. I finally had a Saturday where I cleaned, cooked, and still had energy to meet friends.”
Sofia R., 44

Verified Buyer
Get Your First Bottle
Why GloSerene™ Delivers Real Transformation
GloSerene™ Generic Magnesium Glycinate
Clear, research-inspired daily dose ✔ ✖
Gentle on sensitive digestion ✔ !
Designed for midlife women’s sleep, legs & calm* ✔ ✖
Supports deeper sleep, muscle comfort, mood ✔ ✖
Simple, transparent formula (no mystery blends) ✔ !
Consistent, real multi-symptom relief ✔ ✖
90-day “love it or refund” guarantee ✔ ✖
Made in USA, GMP/FDA facility ✔ !
Every purchase helps women’s wellbeing (donation) ❤ ✖
Why GloSerene™ Delivers Real Transformation
GloSerene™ Generic Magnesium Glycinate
Clear, research-inspired daily dose ✔ ✖
Gentle on sensitive digestion ✔ !
Designed for midlife women’s sleep, legs & calm* ✔ ✖
Supports deeper sleep, muscle comfort, mood ✔ ✖
Simple, transparent formula (no mystery blends) ✔ !
Consistent, real multi-symptom relief ✔ ✖
90-day “love it or refund” guarantee ✔ ✖
Made in USA, GMP/FDA facility ✔ !
Every purchase helps women’s wellbeing (donation) ❤ ✖

*These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure or prevent any disease. Results build with daily use.

Expert-Backed Support for Your Best Nights

This isn’t just science—it’s women helping women. GloSerene was built for your journey, by experts who get what midlife feels like. You deserve better sleep and relief, every night, without second-guessing. You’re part of a community that puts wellbeing first.

We're All Going There

Menopause touches every woman—yet too many feel dismissed, anxious, and alone. Glomend donates 1% of net profits to support women's mental health during this stage, building the community and resources we all deserve.

Founded by women, for women—at every stage.

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Why Magnesium Glycinate Makes All the Difference

Magnesium (from 2,500 mg Magnesium Glycinate) — 275 mg, clinical dose

Clinically shown to calm restless legs, ease muscle tension, and help you fall asleep faster. Specially chosen for midlife women—this gentle, highly absorbable magnesium supports deeper sleep and better mornings, without upsetting your stomach.

Frequently Asked Questions

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Who is GloSerene™ for?

GloSerene™ is designed for women (and men) age 36+ who face tight muscles, restless legs, cramps, or sleep troubles. Whether or not you’re in menopause, it supports your body’s natural calm and rest.

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What if my main problem is anxiety and a racing mind, not leg cramps?

That’s very common. Magnesium glycinate in GloSerene helps relax your muscles and calm your nervous system so your body can settle for sleep. For extra support with a busy or racing mind, many women combine GloSerene with GloRest—a supplement designed specifically to ease mental stress and promote deeper relaxation. Together, they work synergistically to help your whole body unwind naturally.*

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How long will it take to notice a difference?

Many feel calmer legs in a few nights. Sleep usually improves within 1–4 weeks with regular use. If you don’t notice improvement by 4–6 weeks, it may not be right for you.

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Why is GloSerene more expensive than generic magnesium?

Generic magnesium often uses forms that absorb poorly and upset your stomach. GloSerene uses gentle, clinically studied glycinate, made in FDA-registered, GMP-certified labs—designed for real midlife results.

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Will GloSerene make me groggy in the morning?

No. It relaxes your body naturally without sedation. Most women wake up refreshed. If you feel heavy, try taking it earlier or lower your dose.

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Is it safe to take with my medications?

Magnesium is generally safe but can interact with blood pressure, heart, thyroid, diuretics, or mood medications. Always consult your doctor before starting if you take prescriptions.

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What if I have kidney, heart, or blood pressure issues?

If you have kidney problems, only take magnesium with doctor approval. For heart or blood pressure conditions, check with your healthcare provider first.

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I have a very sensitive stomach. Will this upset it or cause diarrhea?

Glycinate is one of the gentlest forms and usually doesn’t cause digestion issues like other magnesium types. Start with 1 capsule with food and increase as you tolerate.

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How should I start if I’m sensitive to supplements?

Start slow: 1 capsule with dinner in week 1, then 2 capsules in week 2, and up to 3 after that as needed.

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Will it make me dependent?

No. Magnesium is a mineral your body needs daily and doesn’t create dependency like sleep pills.

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What if it doesn’t work for me?

If you don’t see results after consistent use, contact us within 90 days for a full refund—even if your bottle is empty.

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Is GloSerene vegan?

Yes! It uses plant-based vegetarian capsules and contains no animal products or fillers.

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Can I open the capsules?

You can. Mix the powder into food or drinks if preferred.

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Can I take it if I’m pregnant or breastfeeding?

Consult your doctor before taking if you are pregnant or breastfeeding.

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How fast is shipping?

Most orders arrive in 3–5 business days. Check our website for shipping details.